The Human Immunology Project Consortium (HIPC) program, established in 2010 by the NIAID Division of Allergy, Immunology, and Transplantation (DAIT), is a major collaborative effort that is generating large amounts of cross-center and cross-assay data — including high-dimensional data — to characterize the status of the immune system in diverse populations under normal conditions and in response to various stimuli. This program has given birth to ImmuneSpace, a powerful data management and analysis engine where datasets can be easily explored and analyzed using state-of-the-art computational tools. To support the wide range of immunological experiments, HIPC is taking advantage of the considerable infrastructure already developed as part of the NIAID Immunology Database and Analysis Portal (ImmPort) system, which serves as a repository of data generated by investigators funded by DAIT.
The original HIPC consortium was composed of seven core centers, located at the Baylor Research Institute, the Dana-Farber Cancer Institute, Emory University, the Mayo Clinic, Seattle Biomed and the Fred Hutchinson Cancer Research Center, Stanford University, and Yale University. In 2015, DAIT awarded three centers in response to the HIPC renewal funding opportunity, RFA-AI-14-007. These centers are located at Emory University, La Jolla Institute, and Icahn School of Medicine at Mount Sinai. Additional centers that have since joined are Boston Children's Hospital, Center for Infectious Desease Research, Columbia University, Drexel University, University of California Los Angeles, and Yale University. For more information about HIPC, please visit the consortium's website.
Data exchange flow and relationship to ImmPort:
As explained in Gottardo et al. (2013) data are submitted to ImmPort by each HIPC center using a set of standardized data templates. Then, once public, these HIPC data are transferred to ImmuneSpace to enable integrative modeling across data types and HIPC centers. The data exchange flow is summarized in the diagram below:
Note that since ImmuneSpace data are transferred directly from ImmPort, ImmuneSpace use the same accession number for consistency. So if you have worked with ImmPort data in the past, you might be able to find these data in ImmuneSpace too (not all ImmPort data are transferred to ImmuneSpace).
About the ImmuneSpace team:
ImmuneSpace is funded by NIAID and is being developed in collaboration with LabKey Software. The project is lead by Dr. Gottardo of the Fred Hutchinson Cancer Research Center. Members of our team include: